How to Pronounce CADASIL
Definition, meaning, and phonetic spelling
CADASIL Pronunciation
kah-DAZ-il
Stressed syllable in ALL CAPS · hyphens separate syllables
Syllable Breakdown
kah
DAZ
stress here
il
3 syllables
What is CADASIL?
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy — the most common hereditary stroke disorder, caused by NOTCH3 gene mutations that damage small blood vessels in the brain, leading to recurrent strokes, migraine, and dementia.
Questions About CADASIL
How do you pronounce CADASIL?
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CADASIL is pronounced "kah-DAZ-il." The stress falls on the second syllable (DAZ), so you say it a bit louder and longer than the other parts. A common mistake is stressing the first syllable instead—remember to put the emphasis on DAZ.
How do you break CADASIL into syllables?
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CADASIL breaks into four syllables: ca-da-sil. Think of it like saying "CAH" (like the 'a' in "cat"), then "DAZ" (rhymes with "jazz"), then "il" (like the end of "pencil"). When you say them together quickly, you get the full word.
What does the abbreviation CADASIL stand for?
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CADASIL stands for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. It's a long medical name, which is why doctors and medical professionals usually just say or write "CADASIL" instead of the whole thing.
What do the word parts in CADASIL mean?
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The first part, "cerebral," refers to the brain. "Autosomal dominant" describes how the condition runs in families—it comes from a single gene passed down from one parent. "Arteriopathy" means a disease of the arteries (small blood vessels). "Infarcts" refers to damaged tissue, and "leukoencephalopathy" means changes in the brain's white matter.
What is a simple, everyday way to understand what CADASIL is?
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CADASIL is a hereditary condition that affects the tiny blood vessels in the brain. In plain terms, it's a genetic disorder passed down through families that impacts how blood flows in the brain, and it's the most common inherited form of stroke disorder.
What is a common mispronunciation of CADASIL?
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A common mistake is saying "CAD-uh-sil" with the stress on the first syllable. The correct way is "kah-DAZ-il" with the stress on the second syllable. Remember: the middle part (DAZ) gets the emphasis, not the beginning.
Can you use CADASIL in a sentence?
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Here's an example: "Her doctor explained that CADASIL runs in her family because her mother carries a mutation in the NOTCH3 gene." This shows how the word is used in medical conversation to name the specific condition.
Are there related medical words that share roots with CADASIL?
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Yes! "Cerebral" appears in other brain-related words like "cerebrovascular." "Arteriopathy" shares its root with words like "artery" and "arteriosclerosis." "Leukoencephalopathy" connects to other brain-matter conditions. Learning these smaller word parts helps you understand and remember medical terms.

